ABIRAPRO

Brand Name: ABIRAPRO
Contents: Abiraterone Acetate
Form: Tablets
Strength: 250 MG
Manufactured By: Glenmark
Packing: 120 tabs

Description :

What is it used for?

Prostate cancer that has spread to other parts of the body.

Treatment with Abirapro is used for men whose cancer is resistant to medical or surgical castration. It may be used before chemotherapy, or for cancer that has progressed on or after a chemotherapy regimen containing docetaxel.

Men having treatment with an LHRH analogue should continue this treatment as well as taking Abirapro
Abirapro is used in combination with a steroid medicine called prednisone or prednisolone. The steroid is given to reduce the chances of fluid retention, raised blood pressure or a drop in the level of potassium in your blood as a result of the Abirapro treatment.

How does it work?

Abirapro tablets contain the active ingredient abiraterone acetate, which is a type of medicine known an androgen biosynthesis inhibitor or an anti-androgen. (Androgens are male sex hormones such as testosterone.) Abirapro is used in the treatment of prostate cancer that has spread beyond the prostate gland.

Prostate cancers are sensitive to testosterone and their growth is increased in the presence of this hormone. Testosterone is produced by the testicles, the adrenal glands and by cells in the prostate tumour itself.

Standard treatment for prostate cancer that has spread beyond the prostate gland involves stopping the production of testosterone by the testicles, in order to slow the growth of the cancer cells. This is usually acheived with medicines called LHRH or gonadorelin analogues, or with surgery to the testicles. However, for some men this treatment does not work.

Abiraterone is used for prostate cancers that are resistant to medical or surgical castration. It works by preventing the action of an enzyme called cytochrome P17, which is also involved in the production of testosterone. This enzyme is found in the testicles, the adrenal glands and the tissues of the prostate tumour. By inhibiting the activity of this enzyme in all these places, the amount of testosterone in the body is decreased more than by medical or surgical castration. This helps to reduce the growth of the prostate cancer cells.

Warning!

This medicine may cause liver problems. For this reason your doctor will want you to have blood tests to monitor your liver function (liver function tests) before starting treatment, every two weeks for the first three months of treatment and then monthly throughout treatment with this medicine. Consult your doctor promptly if you develop unexplained itching, yellowing of the skin or whites of the eyes (jaundice), unusually dark urine, nausea and vomiting, abdominal pains, loss of appetite or flu-like symptoms while taking this medicine, as these could be signs of a liver problem and your dose may need reducing.

Your blood pressure and the level of potassium in your blood should also be checked every month while you are having treatment with this medicine. You should tell your doctor if you notice any signs of fluid retention (for example swollen ankles or gaining weight), or if you get symptoms of low potassium (such as twitching, muscle weakness or a pounding heartbeat) during your treatment.

While taking this medicine you should use a condom if you have sex with a woman who is pregnant. If you have sex with a women who could get pregnant you should use a condom and another method of contraception. This is because it is not known if this medicine passes into semen, however if it does it could be harmful to a developing baby.

Women who are or could be pregnant should wear gloves if they need to touch or handle Abirapro tablets.

Use with caution in

Decreased liver function.

Severely decreased kidney function.

People with a history of heart disease, such as heart failure, an irregular heartbeat, prior heart attack or angina.
High blood pressure (this should be controlled before treatment is started).
People with a low level of potassium in their blood (this should be corrected before treatment is started).
People on a low sodium diet. (Abirapro tablets contain sodium).

Not to be used in Women.

Men with severely decreased liver function.

Abirapro tablets contain lactose and should not be taken by people with rare hereditary problems of galactose intolerance, the lapp lactase deficiency or glucose-galactose malabsorption.

This medicine should not be used if you are allergic to any of its ingredients. Please inform your doctor or pharmacist if you have previously experienced such an allergy.

If you feel you have experienced an allergic reaction, stop using this medicine and inform your doctor or pharmacist immediately.

Side effects

Medicines and their possible side effects can affect individual people in different ways. The following are some of the side effects that are known to be associated with this medicine. Just because a side effect is stated here does not mean that all people using this medicine will experience that or any side effect.

Very common

Urinary tract infections.

Low levels of potassium in the blood (hypokalaemia).

High blood pressure.

Swollen ankles caused by fluid retention (peripheral oedema).

Common Indigestion.

Elevated levels of fats called triglycerides in the blood.
Heart failure.

Angina.

Increased heart rate (tachycardia).
Irregular heartbeats (arrhythmias), including atrial fibrillation.
Elevated levels of liver enzymes.
Rash.
Blood in the urine.
Fractures.

Uncommon

Decreased production of natural steroid hormones from the adrenal glands (adrenocortical insufficiency).
The side effects listed above may not include all of the side effects reported by the medicine’s manufacturer.
For more information about any other possible risks associated with this medicine, please read the information provided with the medicine or consult your doctor or pharmacist.