Eltrombopag Olamine Tablet

Brand Name: Revolade
Generic Name: Eltrombopag olamine
Contents: Eltrombopag olamine
Form: Tablets
Manufacturer Glaxosmith Kline
Available In: 25mg / 50mg
Packing: price per Strip of 7 tabs

Indications Adult chronic immune (idiopathic) thrombocytopenic purpura (ITP) splenectomised patients refractory to other treatments (eg corticosteroids, Ig). 2nd-line treatment for adult nonsplenectomised patients where surgery is contraindicated.

Dosage Individualised dosage based on the patient’s platelet count. Adult Initially 50 mg once daily. East Asian patient 25 mg once daily. Then, adjust dose to maintain platelet count ≥50,000/microliter. Max: 75 mg daily.

Administration Should be taken on an empty stomach (Take at least 4 hr before or after antacids, dairy products or other Ca-containing food products or mineral supplements containing polyvalent cations.).

Special Precautions Not established for use in other thrombocytopenic conditions. Regularly monitor clinical haematology, platelet counts & serum liver test throughout therapy. Renal & hepatic impairment; hepatic disease. Thrombotic/thromboembolic complications. Increased risk of bleeding upon discontinuation of treatment. Bone marrow reticulin formation & risk of bone marrow fibrosis. Malignancies & progression of malignancies. Pregnancy & lactation. Childn <18 yr, elderly.

Adverse Drug Reactions Insomnia; headache, paraesthesia; cataract, dry eye; nausea; GI & hepatobiliary disorders; rash, pruritus, alopecia; arthralgia, myalgia, muscle spasm, bone pain; fatigue, peripheral oedema; thromboembolic events.

Drug Interactions Antacids, dairy products & other products containing polyvalent cations (eg Fe, Ca, Mg, Al, Se, Zn). HMG-CoA reductase inhibitors, methotrexate, topotecan, lopinavir, ritonavir, other drugs for the treatment of ITP.