Trioday Tablets (Efavirenz + Lamivudine + Tenofovir )

Trioday Tablets (Efavirenz + Lamivudine + Tenofovir )

Brand Name: Trioday
Contents: Efavirenz … 600 mg
Lamivudine … 300 mg
Tenofovir disoproxil fumarate … 300 mg
Form: Tablets
Manufacturer Cipla India Ltd
Packing: Price Per Pack of 30 tabs
TRIODAY Tablets are contraindicated in patients with previously demonstrated clinically significant hypersensitivity (e.g., Stevens-Johnson syndrome, erythema multiforme, or toxic skin eruptions) to efavirenz, a component of TRIODAY Tablets .

TRIODAY Tablets should not be administered concurrently with astemizole, bepridil, cisapride, midazolam, pimozide, triazolam or ergot derivatives because competition for CYP3A4 by efavirenz could result in the inhibition of the metabolism of these drugs and create the potential for serious and/or life-threatening adverse events (e.g., cardiac arrhythmias, prolonged sedation, or respiratory depression). TRIODAY Tablets should not be administered concurrently with voriconazole because efavirenz significantly decreases voriconazole plasma concentrations (see WARNINGS AND PRECAUTIONS, Drug Interactions ).

TRIODAY Tablet s are indicated for the treatment of HIV-1 infection in adults.
The dosage of TRIODAY Tablets is one tablet once daily.

It is recommended that TRIODAY Tablets be taken on an empty stomach, preferably at bedtime. Bedtime dosing may improve the tolerability of nervous system symptoms associated with efavirenz. The increased efavirenz concentrations observed following administration of efavirenz with food may lead to an increase in the frequency of adverse events.

Renal Impairment
Reduction of the dose of lamivudine and adjustment in the dosing interval of tenofovir DF is recommended for patients with baseline creatinine clearance <50 mL/min. Hence, TRIODAY Tablets are not suitable for use in this patient population. No data are available to make dose recommendations in adolescent patients with renal impairment.

Pediatric Use
TRIODAY Tablets are not indicated for use in pediatric patients.